TGFβ superfamily signaling and uterine decidualization
نویسندگان
چکیده
منابع مشابه
TGFβ superfamily signaling and uterine decidualization
Decidualization is an intricate biological process where extensive morphological, functional, and genetic changes take place in endometrial stromal cells to support the development of an implanting blastocyst. Deficiencies in decidualization are associated with pregnancy complications and reproductive diseases. Decidualization is coordinately regulated by steroid hormones, growth factors, and m...
متن کاملA distinct cohort of the TGFβ superfamily members expressed in human endometrium regulate decidualization
BACKGROUND Successful blastocyst implantation requires the differentiation of human endometrial stromal cells (HESC), a process known as decidualization. Activin A, a transforming growth factor beta (TGFbeta) superfamily member, enhances HESC decidualization and localizes to decidual cells in human endometrium. Other TGFbeta superfamily members, including BMP2, BMP4, BMP7, GDF5, GDF8, GDF11, TG...
متن کاملPolycomb repressive complex 1 controls uterine decidualization
Uterine stromal cell decidualization is an essential part of the reproductive process. Decidual tissue development requires a highly regulated control of the extracellular tissue remodeling; however the mechanism of this regulation remains unknown. Through systematic expression studies, we detected that Cbx4/2, Rybp, and Ring1B [components of polycomb repressive complex 1 (PRC1)] are predominan...
متن کاملDesigner TGFβ Superfamily Ligands with Diversified Functionality
Transforming Growth Factor--beta (TGFβ) superfamily ligands, including Activins, Growth and Differentiation Factors (GDFs), and Bone Morphogenetic Proteins (BMPs), are excellent targets for protein-based therapeutics because of their pervasiveness in numerous developmental and cellular processes. We developed a strategy termed RASCH (Random Assembly of Segmental Chimera and Heteromer), to engin...
متن کاملThe Role of Wnt Signaling Pathway on the Expression of TGFβ 1 and TGFβ 2 in Cultured Rat Cortical Astrocytes
Introduction: Astrocytes, the most abundant glia in the central nervous system, modulate neuronal survival and function. Astrocytic functions are mediated by synthesis and secretion of wide ranges of polypeptides through mechanism (s) poorly understood. Among these, TGFβs are synthesized and released by the astrocytes. In this study, the involvement of Wnt signaling pathway on the synthesi...
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ژورنال
عنوان ژورنال: Reproductive Biology and Endocrinology
سال: 2017
ISSN: 1477-7827
DOI: 10.1186/s12958-017-0303-0